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Complex Limb Salvage with Placental-Based Allografts: A Pilot Study

A recent publication in the Surgical Science publication looks at the use of dHCAM

Commercially available human placental amnion/chorion tis-sue allografts have been successfully used as protective treatment barriers for wounds and diabetic ulcers. Burn and traumatic limb injuries with exposed bone or tendon generally require surgical flaps or amputations for healing. The purpose of this study was to determine if dehydrated human amnion/ chorion membrane allografts (dHACM) with decellularized human collagen matrix (dHCM) could be used to salvage injured human extremities.

Conclusion:

Treatment with hu-man placental-derived allografts provided a protective covering that enabled the healing cascade to generate granulation tissue formation in extremity wounds with exposed tendon and/or bone. In select limb salvage cases, dHACM/dHCM treatment may be a promising alternative to amputations, tissue rearrangements, free tissue flaps or other techniques for resolution of extremity wounds with bone and tendon exposure. 

Thornburg, D.A., Kowal-Vern, A., Tettelbach, W.H., Foster, K.N. and Matthews, M.R. (2021) Complex Limb Salvage with Placental-Based Allo-grafts: A Pilot Study. Surgical Science , 12, 76-94.

Click here to go to Surgical Science for the article

Or download the pdf here

EpiFix evidence overview

For more information on EpiFix please get in touch using the contact form on our website and we will be on hand to help in anyway we can.


EpiFix offer a unique opportunity to support wound healing and other a treatment option when your standard pathways are not working, here are some case study examples of EpiFix in use (note: these are not cases related to the above mentioned study):

Achilles heel case study

DFU case study

⬇️ A patient story – Tracey’s journey with a leg ulcer and how EpiFix helped resolve a 17 year old wound ⬇️
Patient story with Tracey

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