How It Works
Endoform™ Natural Restorative Bioscaffold products work in all phases of healing to stabilise, correct, build and organise tissue. Endoform™ products are made from AROA ECM™ technology and contain more than 150 extracellular matrix (ECM) proteins that enable it to interact with patient’s cells throughout all phases of healing.(1, 2) Endoform™ products are 85% collagen and 15% important secondary molecules, including structural and adhesion proteins, and glycosaminoglycans (GAGs).(1) Endoform™ products only contain components found in tissue extracellular matrix.
During the inflammatory phase, chronic wounds are characterised by elevated wound proteases that limit healing by digesting important dermal proteins.(3) Endoform™ products can help indicate the presence or absence of proteases and restore protease balance.(4, 5) If Endoform™ products are not visible in the wound bed at the time of reapplication, this can indicate elevated wound protease activity. However, if Endoform™ is visible, this can indicate that protease balance has been restored.
Endoform™ products also contain residual vascular channels that facilitate the rapid establishment of a dense capillary network by supporting migrating endothelial cells to establish new vasculature and a robust blood supply to help build new tissue.(6) This process is termed angioconduction.
Endoform™ Natural Restorative Bioscaffold products are indicated for the management of acute and chronic wounds including:
- Partial and full thickness wounds
- Pressure ulcers
- Venous ulcers
- Diabetic ulcers
- Chronic vascular ulcers
- Tunneled / undermined wounds
- Surgical wounds (donor sites, grafts, post Mohs surgery, post laser surgery, podiatry, wound dehiscence)
- Traumatic wounds (abrasions, lacerations, second-degree burns, and skin tears)
- Draining wounds
1. S. Lun, S.M. Irvine, K.D. Johnson, N.J. Fisher, E.W. Floden, L. Negron, S.G. Dempsey, R.J. McLaughlin, M. Vasudevamurthy, B.R. Ward, B.C. May, A functional extracellular matrix biomaterial derived from ovine forestomach, Biomaterials 31(16) (2010) 4517-29. 2. S.G. Dempsey, C.H. Miller, R.C. Hill, K.C. Hansen, B.C.H. May, Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix, J Proteome Res 18(4) (2019) 1657-1668. 3. R. Lobmann, A. Ambrosch, G. Schultz, K. Waldmann, S. Schiweck, H. Lehnert, Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients, Diabetologia 45(7) (2002) 1011-6. 4. G.A. Bohn, Endoform: A Simple Tool to Assess Wound Proteases, Wound Management and Prevention 65(3) (2019) 18-20. 5. L. Negron, S. Lun, B.C.H. May, Ovine forestomach matrix biomaterial is a broad spectrum inhibitor of matrix metalloproteinases and neutrophil elastase, Int Wound J 11(4) (2012) 392-397. 6. Data on file.