Endoform®

Endoform Restorative Bioscaffold and is a unique extracellular matrix (ECM) for use in the healing of acute and chronic wounds. Endoform products support all phases of wound healing and are appropriate for use early in wound management to restore protease balance and advance healing to the proliferative phase.(1)

Endoform products:

  • Provide a natural porous ECM bioscaffold for rapid cell infiltration(2)
  • Contains more than 150 ECM proteins known to be important in wound healing(3)
  • Contain residual vascular channels to support the establishment of new vasculature(4)
  • Can indicate the presence or absence of proteases and help restore protease balance and guide re-application(5)
  • Can be used by any wound care provider from day 1(1)

How It Works

Endoform™ Natural Restorative Bioscaffold products work in all phases of healing to stabilise, correct, build and organise tissue. Endoform™ products are made from AROA ECM™ technology and contain more than 150 extracellular matrix (ECM) proteins that enable it to interact with patient’s cells throughout all phases of healing.(1, 2) Endoform™ products are 85% collagen and 15% important secondary molecules, including structural and adhesion proteins, and glycosaminoglycans (GAGs).(1) Endoform™ products only contain components found in tissue extracellular matrix.

During the inflammatory phase, chronic wounds are characterised by elevated wound proteases that limit healing by digesting important dermal proteins.(3) Endoform™ products can help indicate the presence or absence of proteases and restore protease balance.(4, 5) If Endoform™ products are not visible in the wound bed at the time of reapplication, this can indicate elevated wound protease activity. However, if Endoform™ is visible, this can indicate that protease balance has been restored.

Endoform™ products also contain residual vascular channels that facilitate the rapid establishment of a dense capillary network by supporting migrating endothelial cells to establish new vasculature and a robust blood supply to help build new tissue.(6) This process is termed angioconduction.

Indications

Endoform™ Natural Restorative Bioscaffold products are indicated for the management of acute and chronic wounds including:

  • Partial and full thickness wounds
  • Pressure ulcers
  • Venous ulcers
  • Diabetic ulcers
  • Chronic vascular ulcers
  • Tunneled / undermined wounds
  • Surgical wounds (donor sites, grafts, post Mohs surgery, post laser surgery, podiatry, wound dehiscence)
  • Traumatic wounds (abrasions, lacerations, second-degree burns, and skin tears)
  • Draining wounds

For more on Endoform and education support please click here

1. S. Lun, S.M. Irvine, K.D. Johnson, N.J. Fisher, E.W. Floden, L. Negron, S.G. Dempsey, R.J. McLaughlin, M. Vasudevamurthy, B.R. Ward, B.C. May, A functional extracellular matrix biomaterial derived from ovine forestomach, Biomaterials 31(16) (2010) 4517-29. 2. S.G. Dempsey, C.H. Miller, R.C. Hill, K.C. Hansen, B.C.H. May, Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix, J Proteome Res 18(4) (2019) 1657-1668. 3. R. Lobmann, A. Ambrosch, G. Schultz, K. Waldmann, S. Schiweck, H. Lehnert, Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients, Diabetologia 45(7) (2002) 1011-6. 4. G.A. Bohn, Endoform: A Simple Tool to Assess Wound Proteases, Wound Management and Prevention 65(3) (2019) 18-20. 5. L. Negron, S. Lun, B.C.H. May, Ovine forestomach matrix biomaterial is a broad spectrum inhibitor of matrix metalloproteinases and neutrophil elastase, Int Wound J 11(4) (2012) 392-397. 6. Data on file.

Overview

AROA ECM™ is a proprietary extracellular matrix (ECM) biomaterial containing a rich and complex mix of biological molecules that is the building block for our range of soft tissue repair products.

AROA ECM™ is manufactured from the ovine (sheep) forestomach tissue, sourced exclusively from New Zealand pasture-raised animals.(1) The source tissue is minimally processed to separate tissue layers and decellularize the tissue ECM. The resulting bioscaffold technology has the structure, composition and function of the ECM that is found in all our soft tissues.(1)

A more in depth look at how it works
 

Cells and the surrounding soft tissue extracellular matrix (ECM) constantly interact to modulate tissue physiology in a process called dynamic reciprocity.(1) In this process, matrix components play an important role in regulating tissue growth, maintenance and orchestrating the process of tissue regeneration. AROA ECM™ retains the authentic structure, signaling and substrates of tissue ECM to help guide tissue repair.(2, 3) Furthermore, AROA ECM™ retains the delicate micro-architecture of tissue ECM to influence the way cells attach, migrate, grow and differentiate.(4)

AROA ECM™ contains more than 150 ECM proteins that are known to be important in the healing process including structural proteins, adhesion proteins, proteoglycans, growth factors and basement membrane.(5) Components in the AROA ECM™ are also shown to attract stem cells.(6)

AROA ECM™ also contains residual vascular channels,(7) that facilitate the rapid establishment of a dense capillary network by supporting migrating endothelial cells to establish new vasculature and a robust blood supply to help build new tissue.(8)

AROA ECM™ is non-cross-linked to preserve the native matrix structure and reduce the risk of negative inflammatory responses due to cross-linking.(9) All AROA ECM™ products are shelf stable and terminally sterilized (ethylene oxide).

 

1. S. Lun, S. M. Irvine, K. D. Johnson, N. J. Fisher, E. W. Floden, L. Negron, S. G. Dempsey, R. J. McLaughlin, M. Vasudevamurthy, B. R. Ward and B. C. May: A functional extracellular matrix biomaterial derived from ovine forestomach. Biomaterials, 31(16), 4517-29 (2010) doi:10.1016/j.biomaterials.2010.02.025.

1. G. S. Schultz, J. M. Davidson, R. S. Kirsner, P. Bornstein and I. M. Herman: Dynamic reciprocity in the wound microenvironment. Wound Repair Regen, 19(2), 134-48 (2011) doi:10.1111/j.1524-475X.2011.00673.x. 2. S. Lun, S. M. Irvine, K. D. Johnson, N. J. Fisher, E. W. Floden, L. Negron, S. G. Dempsey, R. J. McLaughlin, M. Vasudevamurthy, B. R. Ward and B. C. May: A functional extracellular matrix biomaterial derived from ovine forestomach. Biomaterials, 31(16), 4517-29 (2010) doi:10.1016/j.biomaterials.2010.02.025.3. S. M. Irvine, J. Cayzer, E. M. Todd, S. Lun, E. W. Floden, L. Negron, J. N. Fisher, S. G. Dempsey, A. Alexander, M. C. Hill, A. O’Rouke, S. P. Gunningham, C. Knight, P. F. Davis, B. R. Ward and B. C. H. May: Quantification of in vitro and in vivo angiogenesis stimulated by ovine forestomach matrix biomaterial. Biomaterials, 32(27), 6351-61 (2011) doi:10.1016/j.biomaterials.2011.05.040. 4. K. H. Sizeland, H. C. Wells, S. J. R. Kelly, K. E. Nesdale, B. C. H. May, S. G. Dempsey, C. H. Miller, N. Kirby, A. Hawley, S. Mudie, T. Ryan, D. Cookson and R. G. Haverkamp: Collagen Fibril Response to Strain in Scaffolds from Ovine Forestomach for Tissue Engineering. ACS Biomater. Sci. Eng., 3(10), 2550–2558 (2017). 5. S. G. Dempsey, C. H. Miller, R. C. Hill, K. C. Hansen and B. C. H. May: Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix. J Proteome Res, 18(4), 1657-1668 (2019) doi:10.1021/acs.jproteome.8b00908. 6. S. G. Dempsey, C. H. Miller, J. Schueler, R. W. F. Veale, D. J. Day and B. C. H. May: A novel chemotactic factor derived from the extracellular matrix protein decorin recruits mesenchymal stromal cells in vitro and in vivo. PLoS One, 15(7), e0235784 (2020) doi:10.1371/journal.pone.0235784. 7. Data on file. 8. N. S. Greaves, S. A. Lqbal, J. Morris, B. Benatar, T. Alonso-Rasgado, M. Baguneid and A. Bayat: Acute cutaneous wounds treated with human decellularised dermis show enhanced angiogenesis during healing. PLoS One, 10(1), e0113209 (2015) doi:10.1371/journal.pone.0113209. 9. L. M. Delgado, Y. Bayon, A. Pandit and D. I. Zeugolis: To cross-link or not to cross-link? Cross-linking associated foreign body response of collagen-based devices. Tissue Eng Part B Rev, 21(3), 298-313 (2015) doi:10.1089/ten.TEB.2014.0290.

 

Endoform brochure

Endoform and a case series on cost reduction

Endoform application guide

Endoform v Promogran comparator

Endoform residual PDF

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